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style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 57-15-8 YesY
ChemSpider 13842993
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C4H7Cl3O
Molar mass 175.5 g/mol
Appearance White solid
Melting point

95–99 °C

Boiling point

167 °C

 YesY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5 % where it lends long term stability to multi-ingredient formulations.

Chemical synthesis

Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide. Recently, Jawwad & Kashif have prepared Chlorobutanol from chloroform and acetone under phase-transfer catalyzed conditions in high yields.

External links


fr:Chlorobutanol hu:Triklórbutanol it:Cloretone zh:三氯叔丁醇