Chlorobutanol
From Self-sufficiency
Chlorobutanol | |
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1,1,1-Trichloro-2-methylpropan-2-ol | |
Other names 1,1,1-trichloro-2-methyl-2-propanol, chlorbutol, chloreton, chloretone, chlortran, trichloro-tert-butyl alcohol, 1,1,1-trichloro-tert-butyl alcohol, 2-(trichloromethyl)propan-2-ol, 1,1,1-trichloro-2-methyl-2-propanol, tert-Trichlorobutyl alcohol, trichloro-tert-butanol, trichlorisobutylalcohol, 2,2,2-trichloro-1,1-dimethylethanol | |
style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
CAS number | 57-15-8 |
ChemSpider | 13842993 |
SMILES | Script error: No such module "collapsible list". |
InChI | Script error: No such module "collapsible list". |
InChI key | OSASVXMJTNOKOY-UHFFFAOYAO |
style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
Molecular formula | C4H7Cl3O |
Molar mass | 175.5 g/mol |
Appearance | White solid |
Melting point |
95–99 °C |
Boiling point |
167 °C |
(what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
Infobox references |
Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5 % where it lends long term stability to multi-ingredient formulations.
Chemical synthesis
Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide. Recently, Jawwad & Kashif have prepared Chlorobutanol from chloroform and acetone under phase-transfer catalyzed conditions in high yields.