A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five known types of dopamine receptors in the human body; they are found in the brain, peripheral nervous system, blood vessels, and the kidney.
Uses and examples
- Used as atypical antipsychotics (coupled with serotonin antagonist effects): clozapine, risperidone, olanzapine, quetiapine, and ziprasidone
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- Parkinsonism – due to effects on the nigrostriatal pathway
- Hyperprolactinaemia – due to effects on the tuberoinfundibular pathway
- Tardive dyskinesia (long term use)
Other side effects may include menstrual dysfunction, low libido, impotence, and galactorrhea.
Other examples include:
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