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Systematic (IUPAC) name
Clinical data
Routes of
CAS Number 791-35-5
ATC code R05DB10 (WHO)
PubChem CID 2795
ChemSpider 2693
Chemical data
Formula C17H20ClNO
Molar mass 289.8 g/mol[[Script error: No such module "String".]]
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Clofedanol (INN) or chlophedianol (BAN) is a centrally-acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009[2]. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[3] and its safety and efficacy data are limited.


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  1. (French) "Clofedanol". BIAM. 1998-07-24. Retrieved 2007-04-15. 
  2. "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Retrieved 2009-09-27. 
  3. "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). 1987-08-12.