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Systematic (IUPAC) name
(5α,6α)-3-methoxy- 17-methyl- 4,5-epoxymorphinan- 6-yl nicotinate
Clinical data
Routes of
Oral, intravenous
Legal status
Legal status
CAS Number 808-24-2
ATC code none
PubChem CID 5464304
Synonyms 6-Nicotinoyldihydrocodeine
Chemical data
Formula C24H26N2O4
Molar mass 406.474 g/mol[[Script error: No such module "String".]]
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Nicodicodeine is an opiate derivative developed as a cough suppressant and analgesic. Synthesized in 1904, it is not commonly used, but has activity similar to other opiates. Nicodicodeine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine. Since the final active metabolite is the slightly stronger opiate dihydromorphine rather than morphine, nicodicodeine can be expected to be marginally more potent and longer acting than nicocodeine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression.