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Systematic (IUPAC) name
1-methoxy- 3-[4-(2-methoxy- 2-phenylethyl)piperazin- 1-yl]- 1-phenylpropan- 2-ol
Clinical data
Routes of
CAS Number 34758-83-3
ATC code R05DB15 (WHO)
PubChem CID 36910
Chemical data
Formula C23H32N2O3
Molar mass 384.512 g/mol[[Script error: No such module "String".]]
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Zipeprol is a centrally acting cough suppressant which acts as a local anaesthetic and may also have mucolytic, antihistamine-like and anticholinergic properties.[1] It is sold with several brand names such as Zinolta and Respilene. It is not available in the United States or Canada and has been discontinued in Europe. It is still available in some countries in Asia and South America.

Zipeprol has been used recreationally and is heavily abused in Korea, mainly for the hallucinations it produces. Such abuse has become an issue due to the seizures and various neurological side effects it causes at high dosages. Many fatalities have been reported.[2]


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  1. Rispat G, Burgi H, Cosnier D, et al. General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity. Arzneimittelforschung. 1976 Apr;26(4):523-30.
  2. Chung H, Park M, Hahn E, et al. Recent trends of drug abuse and drug-associated deaths in Korea. Ann N Y Acad Sci. 2004 Oct;1025:458-64.