|Systematic (IUPAC) name|
|Protein binding||Variable, 92–97% at therapeutic concentrations|
|Metabolism||Hydrolyzed to clofibric acid; hepatic glucuronidation|
|Biological half-life||Highly variable; average 18–22 hours. Prolonged in renal failure|
|Excretion||Renal, 95 to 99%|
|ATC code||C10AB01 (WHO)|
|Molar mass||242.698 g/mol[[Script error: No such module "String".]]|
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|Boiling point||148 to 150 °C (298 to 302 °F)|
Clofibrate (tradename Atromid-S) is a fibrate. It is a lipid lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It is proved that it can increase the level of HDL as well.
The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed that there was excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. These deaths were due to a wide variety of causes other than heart disease, and remain "unexplained".
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