Mevastatin

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Mevastatin
262px
Systematic (IUPAC) name
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
Identifiers
CAS Number 73573-88-3
ATC code none
PubChem CID 64715
Chemical data
Formula C23H34O5
Molar mass 408.534 g/mol[[Script error: No such module "String".]]
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Mevastatin, compactin, ML-236B is a hypolipidemic agent that belongs to the statins class.

It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s and he identified it as a HMG-CoA reductase inhibitor,[1] i.e.; a statin. Mevastatin might be considered the first statin drug,[2] but, although clinical trials on mevastatin were performed in the late 1970s in Japan, it was never marketed.[3] Rather, lovastatin, developed by Merck, was the first statin drug available to the general public.

In vitro it has antiproliferative properties.[4]

High doses inhibit growth and proliferation of melanoma cells.[5]

References

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GI tract
Liver
Simvastatin# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin‡
Niacin and derivatives (HDL and LDL)
Blood vessels
Combinations
Other

M: MET

mt, a/u/y/n/h, r/g/c/p/i, f/s/l/o, m

au/y/n/h, rgcp/i, f/s/l/o, m, epon

meds(A16, C10),intm(a/u/y/n/h, r/g/c/p/i, f/s/o)


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de:Mevastatin

it:Mevastatina

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  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ http://www.world-of-fungi.org/Mostly_Medical/Mark_Gilson/Mark_Gilson.htm "the story of statins"
  3. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. ↑ http://carcin.oxfordjournals.org/cgi/content/abstract/22/7/1061 "HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2" 2001
  5. ↑ http://www.biomedcentral.com/1471-2407/8/9/abstract "The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells" 2008
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