From Self-sufficiency
Jump to: navigation, search
Systematic (IUPAC) name
(3R,5R)-3,5-dihydroxy-7-((1R,2S,6S,8R,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-heptanoic acid
Pharmacokinetic data
Protein binding 50%
Biological half-life 77 hours
CAS Number 81093-37-0
ATC code C10AA03 (WHO)
PubChem CID 54687
DrugBank APRD00328
Chemical data
Formula C23H36O7
Molar mass 424.528 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc..[1] It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.

The U.S. Food and Drug Administration approved generic pravastatin for sale in the United States for the first time on April 24, 2006. Generic pravastatin sodium tablets (10 mg, 20 mg and 40 mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel.[2]


Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

External links


es:Pravastatina fr:Pravastatine it:Pravastatina hu:Pravasztatin nl:Pravastatine pt:Pravastatina

  1. Yoshino G, Kazumi T, Kasama T; et al. (1986). "Effect of CS-514, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on lipoprotein and apolipoprotein in plasma of hypercholesterolemic diabetics". Diabetes Res. Clin. Pract. 2 (3): 179–81. doi:10.1016/S0168-8227(86)80020-1. PMID 3091343. 
  2. "FDA Approves First Generic Pravastatin". Retrieved 2008-01-20.