Diloxanide furoate
From Self-sufficiency
| File:Diloxanide furoate.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
4-[(dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate | |
| Clinical data | |
| Pregnancy category |
|
| Routes of administration | Oral |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 90% (diloxanide) |
| Metabolism | Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation |
| Biological half-life | 3 hours |
| Excretion | Renal (90%), fecal (10%) |
| Identifiers | |
| CAS Number | 3736-81-0 |
| ATC code | P01AC01 (WHO) |
| PubChem | CID 19529 |
| Chemical data | |
| Formula | C14H11Cl2NO4 |
| Molar mass | 328.147 g/mol[[Script error: No such module "String".]] |
Diloxanide furoate is an anti-protozoal drug used in the treatment of Entamoeba histolytica[1] and some other protozoal infections.
Safety and effectiveness
A 13-year study conducted by the United States Center for Disease Control between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of Entamoeba histolytica. [2]
Availability by country
United States: Not currently approved for use. A CDC study authorized the use of this drug in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990. [2]
References
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<references />, or <references group="..." />- ↑ Fernandes H, D'Souza CR, Swethadri GK, Naik CN (2009). "Ameboma of the colon with amebic liver abscess mimicking metastatic colon cancer". Indian J Pathol Microbiol. 52 (2): 228–30. doi:10.4103/0377-4929.48927. PMID 19332922.
- ↑ 2.0 2.1 McAuley JB, Herwaldt BL, Stokes SL; et al. (1992). "Diloxanide furoate for treating asymptomatic Entamoeba histolytica cyst passers: 14 years' experience in the United States". Clin. Infect. Dis. 15 (3): 464–8. PMID 1520794.
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- World Health Organization essential medicines
- Antiprotozoal agents
- Furans
- Acetanilides
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