Diloxanide furoate

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Diloxanide furoate
File:Diloxanide furoate.svg
Systematic (IUPAC) name
4-[(dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate
Clinical data
  • No available data
Routes of
Legal status
Legal status
  • Not approved (US, CA)
Pharmacokinetic data
Bioavailability 90% (diloxanide)
Metabolism Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation
Biological half-life 3 hours
Excretion Renal (90%), fecal (10%)
CAS Number 3736-81-0
ATC code P01AC01 (WHO)
PubChem CID 19529
Chemical data
Formula C14H11Cl2NO4
Molar mass 328.147 g/mol[[Script error: No such module "String".]]
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Diloxanide furoate is an anti-protozoal drug used in the treatment of Entamoeba histolytica[1] and some other protozoal infections.

Safety and effectiveness

A 13-year study conducted by the United States Center for Disease Control between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of Entamoeba histolytica. [2]

Availability by country

United States: Not currently approved for use. A CDC study authorized the use of this drug in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990. [2]


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  1. Fernandes H, D'Souza CR, Swethadri GK, Naik CN (2009). "Ameboma of the colon with amebic liver abscess mimicking metastatic colon cancer". Indian J Pathol Microbiol. 52 (2): 228–30. doi:10.4103/0377-4929.48927. PMID 19332922. 
  2. 2.0 2.1 McAuley JB, Herwaldt BL, Stokes SL; et al. (1992). "Diloxanide furoate for treating asymptomatic Entamoeba histolytica cyst passers: 14 years' experience in the United States". Clin. Infect. Dis. 15 (3): 464–8. PMID 1520794.