Trimetrexate
From Self-sufficiency
File:Trimetrexate.svg | |
Systematic (IUPAC) name | |
---|---|
5-methyl-6-[(3,4,5-trimethoxyphenyl) aminomethyl] quinazoline-2,4-diamine | |
Pharmacokinetic data | |
Bioavailability | VD: 20-30 Liters |
Metabolism | Oxidative O-demethylation, followed by conjugation with glucuronide or sulfate |
Biological half-life | 11 to 12 hours |
Identifiers | |
CAS Number | 52128-35-5 |
ATC code | P01AX07 (WHO) |
PubChem | CID 5583 |
DrugBank | APRD00268 |
Chemical data | |
Formula | C19H23N5O3 |
Molar mass | 369.418 g/mol[[Script error: No such module "String".]] |
(verify) |
Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.[1]
Uses
It has been used with leucovorin in treating pneumocystis pneumonia.[2]
It has been investigated for use in treating leiomyosarcoma.[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. [4]
References
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External links
50px | This antiinfective drug article is a stub. You can help ssf by expanding it. |
- ↑ Wong BK, Woolf TF, Chang T, Whitfield LR (1990). "Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog". Drug Metab. Dispos. 18 (6): 980–6. PMID 1981548.
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- ↑ Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.
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