Disopyramide

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Disopyramide
File:Disopyramide.svg
File:Disopramide.png
Systematic (IUPAC) name
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
Clinical data
Pregnancy
category
  • AU: B2
  • US: C (Risk not ruled out)
Routes of
administration
Oral, intravenous
Legal status
Legal status
Pharmacokinetic data
Bioavailability High
Protein binding 50% to 65%
(concentration-dependent)
Metabolism Hepatic (CYP3A4-mediated)
Biological half-life 6.7 hours (range 4 to 10 hours)
Excretion Renal (80%)
Identifiers
CAS Number 3737-09-5
ATC code C01BA03 (WHO)
PubChem CID 3114
DrugBank APRD00507
ChemSpider 3002
Chemical data
Formula C21H29N3O
Molar mass 339.475 g/mol[[Script error: No such module "String".]]
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Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

Cardiac adverse effects

Extracardiac effects

Chemistry

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U.S. Patent 3,225,054

External links


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es:Disopiramida fr:Disopyramide hr:Diizopiramid it:Disopiramide pl:Dizopiramid