Bretylium

Bretylium
	File:Bretylium.svg
Systematic (IUPAC) name
	N-(2-bromobenzyl)-N,N-dimethylethanaminium
Clinical data
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	IV, IM
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	NA
Protein binding	NA
Metabolism	None
Biological half-life	7-8 hours
Excretion	Renal
Identifiers
CAS Number	59-41-6
ATC code	C01BD02 (WHO)
PubChem	CID 2431
DrugBank	APRD00830
ChemSpider	2337
Chemical data
Formula	C11H17BrNScript error: No such module "String".
Molar mass	243.163 g/mol[[Script error: No such module "String".]]
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Bretylium (also bretylium tosylate) is an antiarrhythmic agent.^[1] It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. The dose is 5-10 mg/kg and side effects are hypertension followed by hypotension and ventricular ectopy.

It was patented in 1978 by Marvin Bacaner at the University of Minnesota.^[2]

Uses

Bretylium is only used in an ICU setting and should not be used elsewhere due to its dramatic actions and its predominant side effect of hypotension.

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v t e Channel blocker: potassium channel blockers
Antiarrhythmic III/delayed rectifier	benzofuran (Amiodarone) • quaternary ammonium (Bretylium) • naphthalene (Bunaftine) • phenethylamine (Dofetilide) • sulfonamide (Ibutilide) • pyrimidinone (Nifekalant) • ethanolamine (Sotalol) • cyclopropane (Tedisamil) • E-4031
Other/ungrouped/unknown	aminopyridine (3,4-Diaminopyridine, 4-Aminopyridine) • indole (Linopirdine, Paxilline) • quaternary ammonium (Tetraethylammonium) • peptide (Maurotoxin, Charybdotoxin)

Systematic (IUPAC) name
File:Bretylium.svg
N-(2-bromobenzyl)-N,N-dimethylethanaminium
Clinical data
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	IV, IM
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	NA
Protein binding	NA
Metabolism	None
Biological half-life	7-8 hours
Excretion	Renal

Identifiers
CAS Number	59-41-6
ATC code	C01BD02 (WHO)
PubChem	CID 2431
DrugBank	APRD00830
ChemSpider	2337
Chemical data
Formula	C₁₁H₁₇BrN^{Script error: No such module "String".}
Molar mass	243.163 g/mol_{[[Script error: No such module "String".]]}
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