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Systematic (IUPAC) name
Clinical data
  • US: B (No risk in non-human studies)
Routes of
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability >95%
Metabolism Not metabolized[citation needed]
Biological half-life 12 hours
Excretion Renal
Lactic (In lactating females)
CAS Number 3930-20-9
ATC code C07AA07 (WHO)
PubChem CID 5253
DrugBank DB00489
Chemical data
Formula C12H20N2O3S
Molar mass 272.3624 g/mol[[Script error: No such module "String".]]
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Sotalol (trade names Betapace and Betapace AF, Berlex Laboratories, Sotalex and Sotacor, Bristol-Myers Squibb) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.

Sotalol is a non-selective beta blocker. It is also a potassium channel blocker and is therefore a class III anti-arrhythmic agent. Because of this dual-action, Sotalol prolongs both the PR interval and the QT interval.


Sotalol is used to treat ventricular tachycardias[1] as well as atrial fibrillation.[2] Betapace AF is specifically labeled for atrial fibrillation.

Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to an increased risk of death.[3]

It has also been suggested that it be used in the prevention of atrial fibrillation.[4]


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es:Sotalol hr:Sotalol it:Sotalolo hu:Szotalol nl:Sotalol pl:Sotalol pt:Sotalol ru:Соталол fi:Sotaloli

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  3. Waldo A, Camm A, deRuyter H, Friedman P, MacNeil D, Pauls J, Pitt B, Pratt C, Schwartz P, Veltri E (1996). "Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol". Lancet. 348 (9019): 7–12. doi:10.1016/S0140-6736(96)02149-6. PMID 8691967. 
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