Hitachimycin
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| File:Hitachimycin.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
(2Z,4E,6E,12E)-16,20-dihydroxy-21-methoxy- 3-methyl-10-phenyl-9-azabicyclo[17.3.0] docosa-2,4,6,12,19-pentaene-8,18-dione | |
| Identifiers | |
| CAS Number | 77642-19-4 |
| ATC code | none |
| PubChem | CID 5384563 |
| Chemical data | |
| Formula | C29H35NO5 |
| Molar mass | 477.592 g/mol[[Script error: No such module "String".]] |
Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.[2]
As of 2007, it has not been used in a clinical setting.
References
- ↑ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. PMID 6833150.
- ↑ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. PMID 7275806.
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