Polidocanol

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Polidocanol
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Systematic (IUPAC) name
2-[2-[2-[2-[2-[2-[2-[2-[2-(Dodecyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Identifiers
CAS Number 3055-99-0
ATC code C05BB02 (WHO)
PubChem CID 656641
Chemical data
Formula C30H62O10
Molar mass 582.81 g/mol[[Script error: No such module "String".]]
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Polidocanol is a sclerosant, an irritant injected to treat varicose veins.[1] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity. Current research is involved in development of polidocanol as a topical therapy, where systemic safety might no longer be an issue.

The FDA has approved Chemische Fabrik Kreussler & Co.’s Asclera (polidocanol) injection for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Asclera works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue. [2]

Synonyms

  • Polydocanol
  • Laureth 9
  • Macrogol lauryl ether
  • Lauromacrogols
  • (mixed macrogols)
  • PEG-9 lauryl alcohol
  • POE-9 lauryl alcohol
  • Ethoxylated alcohols
  • Dodecylnonaoxyethylene glycol monoether
  • Dodecylpolyethyleneglycolether
  • Hydroxyl polyethoxy dodecane
  • Oxypolyethoxydodecane
  • Asclera[3]

References

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Antihemorrhoidals for topical use
Antivaricose therapy
Capillary stabilising agents
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  1. ↑ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
  2. ↑ [1]
  3. ↑ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11. .
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