Pomalidomide

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Pomalidomide
File:Pomalidomide.png
Systematic (IUPAC) name
4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Identifiers
CAS Number 19171-19-8
ATC code none
PubChem CID 134780
Chemical data
Formula C13H11N3O4
Molar mass 273.24 g/mol[[Script error: No such module "String".]]
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Pomalidomide (originally CC-4047), is a derivative of thalidomide and acts as an immunomodulator. It can be taken orally.

Clinical trials

Phase I trial results showed neutropenia was a frequent side effect.[1]

Phase II clinical trials for multiple myeloma and myelofibrosis have reported 'promising results'.[2] [3] [4]

Mechanism

The immunomodulatory effect is probably due to inhibition of TNF-alpha. In vitro it affects erythropoeisis.[5] and enhances antibody-dependent cellular cytotoxicity (ADCC) [6]

See also

References

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External links

Intracellular
(initiation)
Macrolides/
other IL-2 inhibitors
TNF-α inhibitor
Intracellular
(reception)
Extracellular
Serum target
(noncellular)
Cellular target
Unsorted
-cept (Fusion)
  1. ↑ Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation, BJH Apr 2008
  2. ↑ Promising Results From 2 Trials Highlighting Pomalidomide, Presented At ASH
  3. ↑ Promising results from 2 trials highlighting pomalidomide presented at ASH" Dec 2008
  4. ↑ Pomalidomide Therapy in Anemic Patients with Myelofibrosis: Results from a Phase-2 Randomized Multicenter Study
  5. ↑ Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
  6. ↑ Lenalidomide and pomalidomide strongly enhance tumor cell killing in vitro during antibody-dependent cellular cytotoxicity (ADCC) mediated by trastuzumab, cetuximab and rituximab
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