Visilizumab

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Visilizumab
Monoclonal antibody
Type Whole antibody
Source Template:Infobox drug/mab source
Target CD3 receptor
Identifiers
ATC code none
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Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease.[1]

PDL BioPharma, Inc. canceled production of visilizumab following its Phase II/III clinical trials, citing its inefficacy and poor safety profile compared to other drugs on the market as the major reasons.[2] Nevertheless, clinical trials continue for various diseases like multiple myeloma[3] and diabetes mellitus type 1[4][5] as of July 2009.

Visilizumab has also been radiolabelled with technetium-99m for imaging T cells.[6]

References

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pl:Wizylizumab
  1. "PDL BioPharma, Development Pipeline - Nuvion (visilizumab)". Retrieved 2008-02-11. 
  2. "PDL Lands in a Hazard". Retrieved 2009-05-27. 
  3. "Treated T Cells Followed by a Stem Cell Transplant in Treating Patients With Multiple Myeloma". ClinicalTrials.gov. Retrieved 2010-03-15. 
  4. Kaufman, A; Herold, KC (2009). "Anti-CD3 mAbs for treatment of type 1 diabetes". Diabetes/metabolism research and reviews. 25 (4): 302–6. doi:10.1002/dmrr.933. PMID 19319985. 
  5. "Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes". ClinicalTrials.gov. 
  6. Malviya, G; D'alessandria, C; Bonanno, E; Vexler, V; Massari, R; Trotta, C; Scopinaro, F; Dierckx, R; Signore, A (2009). "Radiolabeled Humanized Anti-CD3 Monoclonal Antibody Visilizumab for Imaging Human T-Lymphocytes". Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 50 (10): 1683. doi:10.2967/jnumed.108.059485. PMID 19759100.