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File:Proguanil Structural Formulae.png
File:Proguanil sf.png
Systematic (IUPAC) name
1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl) guanidine
Pharmacokinetic data
Biological half-life ~20 h
CAS Number 500-92-5
ATC code P01BB01 (WHO)
PubChem CID 4923
DrugBank APRD00188
Chemical data
Formula C11H16ClN5
Molar mass 253.731 g/mol[[Script error: No such module "String".]]
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Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug.

Proguanil is effective against sporozoites.

Proguanil hydrochloride is marketed as Paludrine by AstraZeneca.


It works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells.

It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.


Proguanil is usually taken in combination with another anti-malarial drug such as atovaquone[1] (e.g., in the drug Malarone) or chloroquine.[2]

Malarone has fewer side effects than mefloquine, but can be more expensive because it is taken daily.

Proguanil is taken with atovaquone for chloroquine-resistant and multidrug resistant strains of P. falciparum and P. vivax. Proguanil combined with atovaquone is sold under the tradename Malarone (GlaxoSmithKline)


General precaution regarding Proguanil involves watching out for feelings of sullenness and anxiety to a level that is outside the ordinary, when taking over a period of several months.[citation needed] These may come on gradually and may not be immediately attributable to anything in particular.


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External links


es:Proguanil fr:Proguanil it:Proguanil ja:プログアニル pl:Prokwanil

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