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Systematic (IUPAC) name
CAS Number 2447-57-6
ATCvet code QJ01EQ13 (WHO)
PubChem CID 17134
Chemical data
Formula C12H14N4O4S
Molar mass 310.33 g/mol[[Script error: No such module "String".]]
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide often used in combination with pyrimethamine to treat or prevent malaria.[1] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[2]

Sulfadoxine/pyrimethamine combination

Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability.[3]

The combination is considered to be more effective in treating malaria caused by Plasmodium falciparum than that caused by Plasmodium vivax, for which chloroquine is considered more effective, though in the absence of a species-specific diagnosis the sulfadoxine-pyrimethamine combination may be indicated.[4] Due to side effects, however, it is no longer recommended as a routine preventative,[1] but only to treat serious malaria infections or to prevent them in areas where other drugs may not work.[5]

Programmatic use

Sulfadoxine/pyrimethamine has been used in mass drug administrations as well as in intermittent preventive therapy.


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  1. 1.0 1.1 Medical Treatment - Sulphadoxine and Pyrimethamine
  3. Synergistic Antimalarial Activity of Pyrimethamine and Sulfadoxine against Plasmodium falciparum In Vitro - Chulay et al. 33 (3): 325 - American Journal of Tropical Medicine and Hygiene
  4. JAMA - Abstract: Sulfadoxine-Pyrimethamine, Chlorproguanil-Dapsone, or Chloroquine for the Treatment of Plasmodium vivax Malaria in Afghanistan and Pakistan: A Randomized Controlled Trial, May 23/30, 2007, Leslie et al. 297 (20): 2201
  5. Pyrimethamine and Sulfadoxine (Oral Route) -