Sulfadoxine

Sulfadoxine

File:Sulfadoxine.png
Systematic (IUPAC) name
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Identifiers
CAS Number	2447-57-6
ATCvet code	QJ01EQ13 (WHO)
PubChem	CID 17134
Chemical data
Formula	C12H14N4O4S
Molar mass	310.33 g/mol[[]]
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide often used in combination with pyrimethamine to treat or prevent malaria. It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.

Sulfadoxine/pyrimethamine combination

Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability.

The combination is considered to be more effective in treating malaria caused by Plasmodium falciparum than that caused by Plasmodium vivax, for which chloroquine is considered more effective, though in the absence of a species-specific diagnosis the sulfadoxine-pyrimethamine combination may be indicated. Due to side effects, however, it is no longer recommended as a routine preventative, but only to treat serious malaria infections or to prevent them in areas where other drugs may not work.

Programmatic use

Sulfadoxine/pyrimethamine has been used in mass drug administrations as well as in intermittent preventive therapy.

References

es:Sulfadoxina it:Sulfadossina