Tigatuzumab
From Self-sufficiency
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Template:Infobox drug/mab source |
Target | TNFRSF10B (TRAIL-R2) |
Identifiers | |
CAS Number | 918127-53-4 |
ATC code | none |
Chemical data | |
Formula | C6406H9924N1716O2012S46 |
Molar mass | 144.6 kDa[[Script error: No such module "String".]] |
Tigatuzumab (CS-1008) is a monoclonal antibody[1] for the treatment of cancer. As of October 2009[update], a clinical trial for the treatment of pancreatic cancer has been completed,[2] Phase II trials for colorectal cancer[3] and non-small cell lung cancer[4] are running, and a study for ovarian cancer has been approved.[5]
The drug targets member 10b of the tumor necrosis factor receptor superfamily (TNFRSF10B, better known as death receptor 5 or trail receptor 2), a protein overexpressed in many kinds of tumour.[6]
References
- ↑ WHO Drug Information
- ↑ NCI: Combination Therapy Targets Pancreatic Cancer Stem Cells
- ↑ NCI: CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic Colorectal Carcinoma Who Failed First-line Treatment With Oxaliplatin
- ↑ NCI: CS-1008 With Carboplatin/Paclitaxel in Chemotherapy naïve Subjects With Metastatic or Unresectable Non-small Cell Lung Cancer (NSCLC)
- ↑ NCI: Combination Chemotherapy With CS-1008 to Treat Ovarian Cancer
- ↑ NCI: CS-1008
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