Difference between revisions of "Colestipol"
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Latest revision as of 15:47, 19 September 2010
| File:Colestipol.png | |
| Systematic (IUPAC) name | |
|---|---|
|
Copolymer of N'-(2-aminoethyl)-N-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine and 2-(chloromethyl)oxirane | |
| Identifiers | |
| CAS Number | 50925-79-6 |
| ATC code | C10AC02 (WHO) |
| PubChem | CID 62816 |
| DrugBank | DB00375 |
| ChemSpider | 56550 |
| Chemical data | |
| Formula | C11H28ClN5O |
| Molar mass | 281.8260 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
 | This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (March 2010) |
Colestipol is a bile acid sequestrant. It works in the gut trapping bile salts, and preventing them from being reabsorbed.
This leads to decreased enterohepatic recirculation of bile salts, increased synthesis of new bile salts by the liver, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.
Side effects
- Increases in VLDL and TAG synthesis
- Gastrointestinal tract disturbances
- Malabsorption of lipid soluble vitamins (A,D,E,K) and lipid soluble drugs
Contraindications
Colestipol is contraindicated in hypertriglyceridemia.
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