Difference between revisions of "Pravastatin"
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Latest revision as of 08:44, 20 September 2010
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| Systematic (IUPAC) name | |
|---|---|
|
(3R,5R)-3,5-dihydroxy-7-((1R,2S,6S,8R,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-heptanoic acid | |
| Pharmacokinetic data | |
| Protein binding | 50% |
| Biological half-life | 77 hours |
| Identifiers | |
| CAS Number | 81093-37-0 |
| ATC code | C10AA03 (WHO) |
| PubChem | CID 54687 |
| DrugBank | APRD00328 |
| Chemical data | |
| Formula | C23H36O7 |
| Molar mass | 424.528 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
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Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc..[1] It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.
The U.S. Food and Drug Administration approved generic pravastatin for sale in the United States for the first time on April 24, 2006. Generic pravastatin sodium tablets (10 mg, 20 mg and 40 mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel.[2]
References
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es:Pravastatina fr:Pravastatine it:Pravastatina hu:Pravasztatin nl:Pravastatine pt:Pravastatina
th:ปราวาสแตติน- ↑ Yoshino G, Kazumi T, Kasama T; et al. (1986). "Effect of CS-514, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on lipoprotein and apolipoprotein in plasma of hypercholesterolemic diabetics". Diabetes Res. Clin. Pract. 2 (3): 179–81. doi:10.1016/S0168-8227(86)80020-1. PMID 3091343.
- ↑ "FDA Approves First Generic Pravastatin". Retrieved 2008-01-20.
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- Statins
- Bristol-Myers Squibb
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- Cardiovascular system drug stubs
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