Difference between revisions of "Alclometasone"

Latest revision as of 10:07, 20 September 2010

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

• atopic dermatitis
• eczema
• psoriasis
• allergic dermatitis
• contact dermatitis
• actinic dermatitis
• kiss-type allergy
• skin itch

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

• hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
• cutaneous tuberculosis
• chicken pox
• perioral dermatitis
• acne
• rosacea
• open wounds
• trophic ulcers
• viral infection of skin
• skin manifestations of syphilis

Side effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

• burning
• itching
• erythema
• skin reddening
• xerodermia
• skin irritation
• acne
• hypopigmentation
• prickly heat
• folliculitis
• white atrophy
• hypertrichosis
• reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

• Cream; Topical; 0.05%
• Ointment; Topical; 0.05%

External links