Difference between revisions of "Loteprednol"

Loteprednol
	File:Loteprednol etabonate.svg
Systematic (IUPAC) name
	chloromethyl 17-ethoxycarbonyloxy- 11-hydroxy- 10,13-dimethyl-3-oxo- 7,8,9,11,12,14,15, 16-octahydro- 6H-cyclopenta[a] phenanthrene-17-carboxylate
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
Legal status
Legal status	US: ℞-only ;
Identifiers
CAS Number	82034-46-6
ATC code	S01BA14 (WHO)
PubChem	CID 444025
DrugBank	APRD01078
Chemical data
Formula	C24H31ClO7
Molar mass	466.951 g/mol[[Script error: No such module "String".]]
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Latest revision as of 10:07, 20 September 2010

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Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.

Druzgala, P.; Hochhaus, G.; Bodor, N.; J. Steroid Biochem. Mol. Biol. 1991, 38, 149.

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Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol. 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274.

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