Chlorobutanol
From Self-sufficiency
| Chlorobutanol | |
|---|---|
| 1,1,1-Trichloro-2-methylpropan-2-ol | |
| Other names 1,1,1-trichloro-2-methyl-2-propanol, chlorbutol, chloreton, chloretone, chlortran, trichloro-tert-butyl alcohol, 1,1,1-trichloro-tert-butyl alcohol, 2-(trichloromethyl)propan-2-ol, 1,1,1-trichloro-2-methyl-2-propanol, tert-Trichlorobutyl alcohol, trichloro-tert-butanol, trichlorisobutylalcohol, 2,2,2-trichloro-1,1-dimethylethanol | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 57-15-8 
|
| ChemSpider | 13842993 |
| SMILES | Script error: No such module "collapsible list". |
| InChI | Script error: No such module "collapsible list". |
| InChI key | OSASVXMJTNOKOY-UHFFFAOYAO |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C4H7Cl3O |
| Molar mass | 175.5 g/mol |
| Appearance | White solid |
| Melting point |
95–99 °C |
| Boiling point |
167 °C |
 (what is this?) (verify)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5 % where it lends long term stability to multi-ingredient formulations.
Chemical synthesis
Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide. Recently, Jawwad & Kashif have prepared Chlorobutanol from chloroform and acetone under phase-transfer catalyzed conditions in high yields.
