Disopyramide
From Self-sufficiency
File:Disopyramide.svg | |
File:Disopramide.png | |
Systematic (IUPAC) name | |
---|---|
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide | |
Clinical data | |
Pregnancy category | |
Routes of administration | Oral, intravenous |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | High |
Protein binding |
50% to 65% (concentration-dependent) |
Metabolism | Hepatic (CYP3A4-mediated) |
Biological half-life | 6.7 hours (range 4 to 10 hours) |
Excretion | Renal (80%) |
Identifiers | |
CAS Number | 3737-09-5 |
ATC code | C01BA03 (WHO) |
PubChem | CID 3114 |
DrugBank | APRD00507 |
ChemSpider | 3002 |
Chemical data | |
Formula | C21H29N3O |
Molar mass | 339.475 g/mol[[Script error: No such module "String".]] |
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Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.
Cardiac adverse effects
Extracardiac effects
- Dry mouth
- Constipation
- Urinary retention
- Blurred vision
- Glaucoma
- Rash
- Agranulocytosis
Chemistry
External links
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es:Disopiramida fr:Disopyramide hr:Diizopiramid it:Disopiramide pl:Dizopiramid