Pomalidomide
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Revision as of 06:04, 30 March 2010 by حسن علي البط (Talk) (Quick-adding category Glutarimides (using HotCat))
| File:Pomalidomide.png | |
| Systematic (IUPAC) name | |
|---|---|
|
4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | |
| Identifiers | |
| CAS Number | 19171-19-8 |
| ATC code | none |
| PubChem | CID 134780 |
| Chemical data | |
| Formula | C13H11N3O4 |
| Molar mass | 273.24 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Pomalidomide (originally CC-4047), is a derivative of thalidomide and acts as an immunomodulator. It can be taken orally.
Clinical trials
Phase I trial results showed neutropenia was a frequent side effect.[1]
Phase II clinical trials for multiple myeloma and myelofibrosis have reported 'promising results'.[2] [3] [4]
Mechanism
The immunomodulatory effect is probably due to inhibition of TNF-alpha. In vitro it affects erythropoeisis.[5] and enhances antibody-dependent cellular cytotoxicity (ADCC) [6]
See also
- Lenalidomide, another thalidomide analog
References
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<references />, or <references group="..." />External links
- ↑ Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation, BJH Apr 2008
- ↑ Promising Results From 2 Trials Highlighting Pomalidomide, Presented At ASH
- ↑ Promising results from 2 trials highlighting pomalidomide presented at ASH" Dec 2008
- ↑ Pomalidomide Therapy in Anemic Patients with Myelofibrosis: Results from a Phase-2 Randomized Multicenter Study
- ↑ Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
- ↑ Lenalidomide and pomalidomide strongly enhance tumor cell killing in vitro during antibody-dependent cellular cytotoxicity (ADCC) mediated by trastuzumab, cetuximab and rituximab
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