Bombesin
From Self-sufficiency
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| Bombesin | |
|---|---|
| File:Bombesin full.png | |
| Other names Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 31362-50-2 |
| PubChem | 16133891 |
| IUPHAR ligand | 616 |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C71H110N24O18S |
| Molar mass | 1619.85 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Bombesin is a 14-amino acid peptide originally isolated from the skin of a frog. It has two known homologs in mammals called neuromedin B and gastrin releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.
Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, and neuroblastoma.
See also
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de:Bombesin es:Bombesina it:Bombesina nl:Bombesine pl:Bombezyna sl:Bombezin
