Loteprednol
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| File:Loteprednol etabonate.svg | |
| Systematic (IUPAC) name | |
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chloromethyl 17-ethoxycarbonyloxy- 11-hydroxy- 10,13-dimethyl-3-oxo- 7,8,9,11,12,14,15, 16-octahydro- 6H-cyclopenta[a] phenanthrene-17-carboxylate | |
| Clinical data | |
| Pregnancy category |
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| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 82034-46-6 |
| ATC code | S01BA14 (WHO) |
| PubChem | CID 444025 |
| DrugBank | APRD01078 |
| Chemical data | |
| Formula | C24H31ClO7 |
| Molar mass | 466.951 g/mol[[Script error: No such module "String".]] |
| (verify) | |
Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.
Druzgala, P.; Hochhaus, G.; Bodor, N.; J. Steroid Biochem. Mol. Biol. 1991, 38, 149.
http://dx.doi.org/10.1016/0960-0760(91)90120-T
References
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- Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol. 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274.
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