Diloxanide furoate
From Self-sufficiency
File:Diloxanide furoate.svg | |
Systematic (IUPAC) name | |
---|---|
4-[(dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate | |
Clinical data | |
Pregnancy category |
|
Routes of administration | Oral |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 90% (diloxanide) |
Metabolism | Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation |
Biological half-life | 3 hours |
Excretion | Renal (90%), fecal (10%) |
Identifiers | |
CAS Number | 3736-81-0 |
ATC code | P01AC01 (WHO) |
PubChem | CID 19529 |
Chemical data | |
Formula | C14H11Cl2NO4 |
Molar mass | 328.147 g/mol[[Script error: No such module "String".]] |
Diloxanide furoate is an anti-protozoal drug used in the treatment of Entamoeba histolytica[1] and some other protozoal infections.
Safety and effectiveness
A 13-year study conducted by the United States Center for Disease Control between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of Entamoeba histolytica. [2]
Availability by country
United States: Not currently approved for use. A CDC study authorized the use of this drug in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990. [2]
References
Cite error: Invalid <references>
tag;
parameter "group" is allowed only.
<references />
, or <references group="..." />
- ↑ Fernandes H, D'Souza CR, Swethadri GK, Naik CN (2009). "Ameboma of the colon with amebic liver abscess mimicking metastatic colon cancer". Indian J Pathol Microbiol. 52 (2): 228–30. doi:10.4103/0377-4929.48927. PMID 19332922.
- ↑ 2.0 2.1 McAuley JB, Herwaldt BL, Stokes SL; et al. (1992). "Diloxanide furoate for treating asymptomatic Entamoeba histolytica cyst passers: 14 years' experience in the United States". Clin. Infect. Dis. 15 (3): 464–8. PMID 1520794.
Categories:
- Pages with script errors
- Pages with broken file links
- Infobox drug tracked parameters
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Articles containing unverified chemical infoboxes
- 2Fix
- World Health Organization essential medicines
- Antiprotozoal agents
- Furans
- Acetanilides
- Phenols
- Organochlorides
- Furoates
- CS1 maint: Multiple names: authors list
- CS1 maint: Explicit use of et al.