Clobutinol

Clobutinol
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Systematic (IUPAC) name
	(RS)-1-(4-chlorophenyl)- 4-dimethylamino- 2,3-dimethyl- butan- 2-ol
Identifiers
CAS Number	14860-49-2
ATC code	R05DB03 (WHO)
PubChem	CID 26937
ChemSpider	25085
Chemical data
Formula	C14H22ClNO
Molar mass	255.783 g/mol[[Script error: No such module "String".]]
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Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

It was recently determined to cause cardiac arrhythmia in some patients.

Recent studies have indicated that clobutinol has the potential to prolong the QT interval.^[1]^[2].

Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007^[3] ^[4]^[5].

↑ Bellocq C, Wilders R, Schott JJ; et al. (2004). "A common antitussive drug, clobutinol, precipitates the long QT syndrome 2". Mol. Pharmacol. 66 (5): 1093–102. doi:10.1124/mol.104.001065. PMID 15280442.
↑ Expert statement on BfArM website: [1]. Retrieved 2007-SEP-01.
↑ Yahoo! News: Bundesinstitut ruft Hustenmittel zurück [in German]. Retrieved 2007-AUG-31.
↑ tagesschau.de: Bundesinstitut verbietet Hustenmittel Clobutinol [in German]. Retrieved 2007-AUG-31.
↑ Company Website:Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications [English]. Retrieved 2007-Sep-01.

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