Ambrisentan

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Ambrisentan
File:Ambrisentan structure.svg
Systematic (IUPAC) name
(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid
Clinical data
[[Regulation of therapeutic goods |Template:Engvar data]]
Pregnancy
category
  • US: X (Contraindicated)
  • May cause harm to fetus
Routes of
administration		 Oral
Legal status
Legal status
Pharmacokinetic data
Bioavailability Undetermined
Protein binding 99%
Biological half-life 15 hours (terminal)
Identifiers
CAS Number 177036-94-1
ATC code C02KX02 (WHO)
PubChem CID 6918493
ChemSpider 5293690
Chemical data
Formula C22H22N2O4
Molar mass 378.421 g/mol[[Script error: No such module "String".]]
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Ambrisentan (U.S. trade name Letairis; E.U. trade name Volibris) is a drug indicated for use in the treatment of pulmonary hypertension.

It functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).[1]

Ambrisentan was approved for sale by the U.S. Food and Drug Administration (FDA) on June 15, 2007 for the once-daily treatment of pulmonary arterial hypertension.[2][3][4] It was later approved by the European Medicines Agency for use in the EU on April 2008.[5] Ambrisentan had previously been designated an orphan drug by both the FDA and the European Commission, in August 2004 and May 2005 respectively.[6]

Clinical uses

Ambrisentan is indicated for the treatment of pulmonary arterial hypertension (WHO Group 1) in patients with WHO class II or III symptoms to improve exercise capacity and delay clinical worsening.

The LETAIRIS Education and Access Program

The LETAIRIS Education and Access Program (LEAP) is a program to help physicians and patients learn about the risks of LETAIRIS, including the serious risks of liver injury and birth defects.

LEAP works by:

  • Providing information to prescribers on the risks of LETAIRIS
  • Providing comprehensive education to patients and assistance with obtaining LETAIRIS
  • Requiring enrollment of both prescriber and patient in LEAP
  • Controlling dispensing through a specialized distribution network (specialty pharmacies)

External links

References

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Medications used in the management of pulmonary arterial hypertension (B01, C02)
Prostacyclin analogues
Endothelin receptor antagonists
Ambrisentan, Bosentan, Sitaxentan
PDE5 inhibitors
Adjunctive therapy
Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
Adrenergic release inhibitors
Peripheral
Indirect
Direct
Non-selective α blocker
Other antagonists
dual (Bosentan) • selective (Ambrisentan, Sitaxentan)
de:Ambrisentan
  1. ↑ Vatter H, Seifert V (2006). "Ambrisentan, a non-peptide endothelin receptor antagonist". Cardiovasc Drug Rev. 24 (1): 63–76. doi:10.1111/j.1527-3466.2006.00063.x. PMID 16939634. 
  2. ↑ Pollack, Andrew (2007-06-16). "Gilead's Drug Is Approved to Treat a Rare Disease". New York Times. Retrieved 2007-05-25. 
  3. ↑ "U.S. Food and Drug Administration Approves Gilead's Letairis Treatment of Pulmonary Arterial Hypertension" (Press release). Gilead Sciences. 2007-06-15. http://www.gilead.com/wt/sec/pr_1016053. Retrieved 2007-06-16. 
  4. ↑ "FDA Approves New Orphan Drug for Treatment of Pulmonary Arterial Hypertension" (Press release). Food and Drug Administration. 2007-06-15. http://www.fda.gov/bbs/topics/NEWS/2007/NEW01653.html. Retrieved 2007-06-22. 
  5. ↑ "GlaxoSmithKline's Volibris (ambrisentan) receives authorisation from the European Commission for the treatment of Functional Class II and III Pulmonary Arterial Hypertension" (Press release). GlaxoSmithKline. 2008-04-25. http://www.gsk.com/media/pressreleases/2008/2008_pressrelease_10033.htm. Retrieved 2008-04-29. 
  6. ↑ Waknine, Yael (2005-05-09). "International Approvals: Ambrisentan, Oral-lyn, Risperdal". Medscape. Retrieved 2007-06-16. 
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