Ganglionic blocker

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A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits postganglionic transmission,[1] primarily by acting as a nicotinic antagonist.[2]

Because ganglionic blockers block the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system.[3]


Examples include hexamethonium, pentolinium, mecamylamine, trimetaphan, and pempidine.

Others include:[4]


Ganglionic blockers are used less frequently now than they were in the past, because more selective agents are now available. However, they are still used in some emergency situations, such as aortic dissection.


  • Cardiovascular: Orthostatic(postural) hypotension, Tachycardia
  • GIT: Dry-mouth, GIT atony,urine retention, digestive problems
  • Sexual Dysfunction: Failure of erection and ejaculation


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  1. "Dorlands Medical Dictionary:ganglioplegic". 
  2. MeSH Ganglionic+blockers
  3. "PHARMACOLOGY OF GANGLIONIC TRANSMISSION, 1998". Retrieved 2008-10-04. 
  4. MeSH list of agents 82005730