Thiamphenicol
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| 214px | |
| Systematic (IUPAC) name | |
|---|---|
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2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide | |
| Clinical data | |
| Pregnancy category |
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| Routes of administration | IV, IM, oral |
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| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | hepatic |
| Biological half-life | 5.0 hours |
| Excretion | renal |
| Identifiers | |
| CAS Number | 15318-45-3 |
| ATC code | J01BA02 (WHO) QJ51BA02 |
| PubChem | CID 27200 |
| Chemical data | |
| Formula | C12H15Cl2NO5S |
| Molar mass | 356.223 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.[1]
References
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<references />, or <references group="..." />External links
- Overview at World Health Organization - Food and Agriculture Organization
- Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars). 64 (1): 33–8. PMID 15224555.
- Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy". J Chemother. 14 (6): 554–61. PMID 12583545.
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fr:Thiamphénicol nl:Thiamfenicol ja:チアンフェニコール th:ไทแอมเฟนิคอล
zh:甲碸黴素- ↑ Fuchs FD (2004). "Tetraciclinas e cloranfenicol". In Fuchs FD, Wannmacher L, Ferreira MB (eds.). Farmacologia clínica: fundamentos da terapêutica racional (in Portuguese) (3rd ed.). Rio de Janeiro: Guanabara Koogan. p. 375. ISBN 0-7216-5944-6.
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