Cethromycin

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Cethromycin
File:Cethromycin.png
Systematic (IUPAC) name
(1S,2R,5R,7R,8R,9S,11R,13R,14R)-8-[(2S,3R,4S,6R)- 4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13- hexamethyl-9-[(E)-3-quinolin-3-ylprop-2-enoxy] -3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
Clinical data
Routes of
administration
Oral
Legal status
Legal status
Pharmacokinetic data
Bioavailability Between 35.8 and 60 % in animal studies.
Metabolism Liver
Biological half-life 1.6, 3.0, 4.5, 5.9 and 6 hours. Mouse, Monkey, Rat, Dog and Human respectively.
Excretion 7.0% urine 87.2% faeces
Identifiers
CAS Number 205110-48-1
ATC code none
PubChem CID 5282045
Chemical data
Formula C42H59N3O10
Molar mass 765.931 g/mol[[Script error: No such module "String".]]
Physical data
Melting point 211 to 213 °C (412 to 415 °F)
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Cethromycin (initially known as ABT-773[1][2]) is a ketolide antibiotic undergoing research for the treatment of community acquired pneumonia (CAP)[1][3][4][5] and for the prevention of post-exposure inhalational anthrax, and was given an "orphan drug" status for this indication.[6] Originally discovered and developed by Abbott, it was acquired by Advanced Life Sciences Inc. for further development.

On October 1, 2008 Advanced Life Sciences submitted a New Drug Application (NDA) to Food and Drug Administration (FDA) for cethromycin to treat mild-to-moderate community acquired pneumonia.[7]

On December 3, 2008 Advanced Life Sciences announced that this New Drug Application has been accepted for filing by the FDA.[8]

References

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Further reading


de:Cethromycin
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  6. Cethromycin - Advanced Life Sciences
  7. Cethromycin New Drug Application
  8. Cethromycin New Drug Application accepted for filing by FDA