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Systematic (IUPAC) name
Pharmacokinetic data
Protein binding 96 to 98%
Biological half-life 8-9 hours
CAS Number 51264-14-3
ATC code L01XX01 (WHO)
PubChem CID 2179
DrugBank APRD00064
ChemSpider 2094
Chemical data
Formula C21H19N3O3S
Molar mass 393.46 g/mol[[Script error: No such module "String".]]
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Amsacrine is an antineoplastic agent.

It has been used in acute lymphoblastic leukemia.[1]


Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.

Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).[2]


  1. PMID 16330449
  2. Genetic Response to Metals. Sarkar, Bibudhendra. CRC Press, 1995. ISBN 9780824796150