BSPP (drug)

From Self-sufficiency
Jump to: navigation, search
BSPP (drug)
File:BSPP structure.png
Systematic (IUPAC) name
2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol
Identifiers
ATC code none
PubChem CID 16079861
Chemical data
Formula C21H34O2
Molar mass 318.492 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It has a synergistic effect with GABAB agonists such as baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


  1. Kerr DIB, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M. Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols. Australian Journal of Chemistry. 2006;59:457-462.
  2. Parker DA, Marino V, Ong J, Puspawati NM, Prager RH. The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors. Clinical and Experimental Pharmacology and Physiology. 2008 Sep;35(9):1113-5. PMID 18430050