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Systematic (IUPAC) name
bis(2,2,2-trifluoroethyl) ether
CAS Number 333-36-8
ATC code none
PubChem CID 9528
Synonyms Hexafluorodiethyl ether
Chemical data
Formula C4H4F6O
Molar mass 182.064[[Script error: No such module "String".]]
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Physical data
Density 1.404 g/cm3 g/cm3
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Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.[1] Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.[2][3][4] Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.[5][6] This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.[7]


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  1. Rose L, Watson A. Flurothyl (Indoklon). Experience with an inhalational convulsant agent. Anaesthesia. 1967 Jul;22(3):425-34. PMID 4951597
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  5. A convulsant agent for psychiatric use. Flurothyl (Indoklon). Journal of the American Medical Association. 1966 Apr 4;196(1):29-30. PMID 4379572
  6. Small JG, Small IF, Sharpley P, Moore DF. A double-blind comparative evaluation of flurothyl and ECT. Archives of General Psychiatry. 1968 Jul;19(1):79-86. PMID 5658383
  7. Hashimoto Y, Araki H, Suemaru K, Gomita Y. Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. European Journal of Pharmacology. 2006 May 1;536(3):241-7. PMID 16581068