Flurothyl
| File:Flurothyl.png | |
| Systematic (IUPAC) name | |
|---|---|
|
2,2-oxybis(1,1,1-trifluoroethane) OR bis(2,2,2-trifluoroethyl) ether | |
| Identifiers | |
| CAS Number | 333-36-8 |
| ATC code | none |
| PubChem | CID 9528 |
| Synonyms | Hexafluorodiethyl ether |
| Chemical data | |
| Formula | C4H4F6O |
| Molar mass | 182.064[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| Physical data | |
| Density | 1.404 g/cm3 g/cm3 |
Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.[1] Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.[2][3][4] Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.[5][6] This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.[7]
References
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- ↑ Rose L, Watson A. Flurothyl (Indoklon). Experience with an inhalational convulsant agent. Anaesthesia. 1967 Jul;22(3):425-34. PMID 4951597
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- ↑ A convulsant agent for psychiatric use. Flurothyl (Indoklon). Journal of the American Medical Association. 1966 Apr 4;196(1):29-30. PMID 4379572
- ↑ Small JG, Small IF, Sharpley P, Moore DF. A double-blind comparative evaluation of flurothyl and ECT. Archives of General Psychiatry. 1968 Jul;19(1):79-86. PMID 5658383
- ↑ Hashimoto Y, Araki H, Suemaru K, Gomita Y. Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. European Journal of Pharmacology. 2006 May 1;536(3):241-7. PMID 16581068
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