Phenylethylidenehydrazine
From Self-sufficiency
File:Phenylethylidenehydrazine.png | |
Systematic (IUPAC) name | |
---|---|
(1E)-1-ethylidene-2-phenylhydrazine | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Biological half-life | ~12 hours |
Identifiers | |
CAS Number | 935-07-9 |
ATC code | none |
PubChem | CID 6537404 |
ChemSpider | 5020586 |
Chemical data | |
Formula | C8H10N2 |
Molar mass | 134.18 g/mol[[Script error: No such module "String".]] |
Script error: No such module "collapsible list". |
Phenylethylidenehydrazine (PEH) is an inhibitor of the enzyme GABA transaminase (GABA-T).[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders.
See also
References
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- ↑ Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience. 126 (2): 423–32. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360.
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- Hydrazines
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- CS1 maint: Multiple names: authors list