|Systematic (IUPAC) name|
|Molar mass||371.449 g/mol[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
ROD-188 is a sedative drug structurally derived from the GABAA antagonist bicuculline. Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor. ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors.
Cite error: Invalid
parameter "group" is allowed only.
<references />, or
<references group="..." />
|40x30px||This sedative-related article is a stub. You can help ssf by expanding it.|
- Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E. A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. British Journal of Pharmacology. 2000 Oct;131(4):843-50. PMID 11030736
- Sigel E, Baur R, Furtmueller R, Razet R, Dodd RH, Sieghart W. Differential cross talk of ROD compounds with the benzodiazepine binding site. Molecular Pharmacology. 2001 Jun;59(6):1470-7. PMID 11353808