Nedocromil

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Nedocromil
File:Nedocromil.svg
Systematic (IUPAC) name
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-
4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Routes of
administration
Inhalation and eye drops
Legal status
Legal status
Pharmacokinetic data
Protein binding 89%
Metabolism not metabolized
Biological half-life ~3.3 hours
Excretion excreted unchanged
Identifiers
CAS Number 69049-73-6
ATC code R01AC07 (WHO) R03BC03, S01GX04
PubChem CID 50294
DrugBank APRD01137
Chemical data
Formula C19H17NO7
Molar mass 371.341 g/mol[[Script error: No such module "String".]]
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Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[1]

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[2]

References

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  1. "Nedocromil eye drops". 2007-02-02. Retrieved 2009-08-04. 
  2. http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf