Nedocromil
From Self-sufficiency
File:Nedocromil.svg | |
Systematic (IUPAC) name | |
---|---|
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro- 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid | |
Clinical data | |
Routes of administration | Inhalation and eye drops |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 89% |
Metabolism | not metabolized |
Biological half-life | ~3.3 hours |
Excretion | excreted unchanged |
Identifiers | |
CAS Number | 69049-73-6 |
ATC code | R01AC07 (WHO) R03BC03, S01GX04 |
PubChem | CID 50294 |
DrugBank | APRD01137 |
Chemical data | |
Formula | C19H17NO7 |
Molar mass | 371.341 g/mol[[Script error: No such module "String".]] |
(verify) |
Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[1]
Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[2]
References
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45px | This drug article relating to the respiratory system is a stub. You can help ssf by expanding it. |
- ↑ "Nedocromil eye drops". 2007-02-02. Retrieved 2009-08-04.
- ↑ http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf
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