Oxymetazoline

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Oxymetazoline
File:Oxymetazoline structure.png
File:Oxymetazoline 3d.gif
Systematic (IUPAC) name
3-(4,5-dihydro-1H-imidazol-2-ylmethyl)- 2,4-dimethyl-6-tert-butyl-phenol
Clinical data
Pregnancy
category
  • C
Pharmacokinetic data
Biological half-life 5-6 hours
Identifiers
CAS Number 1491-59-4
ATC code R01AA05 (WHO) R01AB07, S01GA04
PubChem CID 4636
IUPHAR/BPS 124
DrugBank APRD01158
Chemical data
Formula C16H24N2O
Molar mass 260.375 g·mol−1[[Script error: No such module "String".]]
Physical data
Melting point 301.5 °C (574.7 °F)
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Clinical uses

Oxymetazoline is available over-the-counter as a topical decongestant in the form of oxymetazoline hydrochloride in nasal sprays such as Afrin, Sudafed OM, Dristan, Vicks Sinex, and Mucinex Full Force.[1] It was developed from Xylometazoline at E.Merck Darmstadt by Fruhstorfer in 1961 (German Patent 1,117,588).

Oxymetazoline is also used to treat epistaxis[2][3] and eye redness due to minor irritation (marketed as Visine L.R. in the form of eye drops).[4]

Mechanism of action

Oxymetazoline is an adrenomimetic that nonselectively agonizes α1 and α2 adrenergic receptors.[5] Since vascular beds widely express α1 receptors, the action of oxymetazoline results in vasoconstriction. In addition, the local application of the drug also results in vasoconstriction due to its action on endothelial postsynaptic α2 receptors; systemic application of α2 agonists, in contrast, causes vasodilation because of centrally-mediated inhibition of sympathetic tone via presynaptic α2 receptors.[6] Vasoconstriction of vessels results in relief of nasal congestion in two ways: firstly, it increases the diameter of the airway lumen; secondly, it reduces fluid exudation from postcapillary venules.[7]

Side effects and special considerations

Rebound congestion

It is recommended that oxymetazoline not be used for more than three days, as rebound congestion, or rhinitis medicamentosa, may occur.[8] Patients who continue to use oxymetazoline beyond this point may become reliant on the medication to relieve their chronic congestion.

Effects of benzalkonium chloride

Some studies have found that benzalkonium chloride, a common additive to oxymetazoline nasal sprays, may damage nasal epithelia and exacerbate rhinitis medicamentosa. However, the majority of studies find benzalkonium chloride to be a safe preservative.[9]

Use in pregnancy

The Food and Drug Administration places oxymetazoline in category C, indicating there may be some risk to the fetus. While it has been shown that a single dose does not significantly alter either maternal or fetal circulation,[10] this subject has not been studied extensively.

Overdose

If accidentally ingested, standard methods to remove unabsorbed drugs should be considered. There is no specific antidote for oxymetazoline, although its pharmacological effects may be reversed by alpha adrenergic antagonists such as phentolamine. In children, oxymetazoline may produce profound central nervous system depression due to stimulation of central alpha-2 receptors and imidazoline receptors, much like clonidine.

References

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Decongestants and other nasal preparations (R01)
Topical
Antiallergic agents,
excluding corticosteroids
Other nasal preparations
Systemic use:
Sympathomimetics

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it:Oximetazolina he:אוקסימטזולין hu:Oximetazolin nl:Oxymetazoline pl:Oksymetazolina pt:Oximetazolina

ru:Оксиметазолин
  1. ↑ http://www.merck.com/mmpe/lexicomp/oxymetazoline.html
  2. ↑ Katz, R.I., et al., A comparison of cocaine, lidocaine with epinephrine, and oxymetazoline for prevention of epistaxis on nasotracheal intubation. J Clin Anesth, 1990. 2(1): p. 16-20
  3. ↑ 13. Krempl, G.A. and A.D. Noorily, Use of oxymetazoline in the management of epistaxis. Ann Otol Rhinol Laryngol, 1995. 104(9 Pt 1): p. 704-6.
  4. ↑ http://www.visine.com/product-visine-original.jsp
  5. ↑ Westfall Thomas C, Westfall David P, "Chapter 6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems" (Chapter). Brunton LL, Lazo JS, Parker KL: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11e: http://www.accessmedicine.com/content.aspx?aID=954433.
  6. ↑ Biaggioni Italo, Robertson David, "Chapter 9. Adrenoceptor Agonists & Sympathomimetic Drugs" (Chapter). Katzung BG: Basic & Clinical Pharmacology, 11e: http://www.accessmedicine.com/content.aspx?aID=4520412.
  7. ↑ J. Widdicombe. Microvascular anatomy of the nose. Allergy 52 (1997), pp. 7–11.
  8. ↑ JT Ramey, E Bailen, RF Lockey. Rhinitis medicamentosa. J Investig Allergol Clin Immunol 2006; Vol. 16(3): 148-155.
  9. ↑ Marple B, Roland P, Benninger M. Safety review of benzalkonium chloride used as a preservative in intranasal solutions: an overview of conflicting data and opinions. Otolaryngol Head Neck Surg. 2004 Jan;130(1):131-41.
  10. ↑ Rayburn WF, Anderson JC, Smith CV, Appel LL, Davis SA. Uterine and fetal Doppler flow changes from a single dose of a long-acting intranasal decongestant. Obstet Gynecol. 1990 Aug;76(2):180-2.
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