Tafenoquine
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| File:Tafenoquine.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl) phenoxy]quinolin-8-yl]pentane-1,4-diamine | |
| Identifiers | |
| CAS Number | 106635-80-7 |
| ATC code | none |
| PubChem | CID 115358 |
| Chemical data | |
| Formula | C24H28F3N3O3 |
| Molar mass | 463.493 g/mol[[Script error: No such module "String".]] |
Tafenoquine (also called WR-238605 or SB-252263) is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is currently being investigated as a potential treatment for malaria, as well as for malaria prevention.[1][2]
The main advantage of tafenoquine is that it has a long half-life and therefore does not need to be taken as frequently as primaquine. Like primaquine, tafenoquine causes haemolysis in people with G-6-PD deficiency.[1]
A shorter regimen has also been described as an advantage.[3]
The dose of tafenoquine has not been firmly established, but for the treatment of Plasmodium vivax malaria, a dose of 800 mg over three days has been used.[4]
References
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- ↑ 1.0 1.1 Shanks GD, Oloo AJ, Aleman GM; et al. (2001). "A New Primaquine Analogue, Tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malaria". Clin Infect Dis. 33 (12): 1968–74. doi:10.1086/324081. PMID 11700577.
- ↑ Lell B, Faucher JF, Missinou MA; et al. (2000). "Malaria chemoprophylaxis with tafenoquine: a randomised study". Lancet. 355 (9220): 2041–5. doi:10.1016/S0140-6736(00)02352-7. PMID 10885356.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Nasvelda P, Kitchener S. (2005). "Treatment of acute vivax malaria with tafenoquine". Trans R Soc Trop Med Hyg. 99 (1): 2–5. doi:10.1016/j.trstmh.2004.01.013. PMID 15550254.
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