Difference between revisions of "Ifosfamide"
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| File:Ifosfamide.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide | |
| Clinical data | |
| Routes of administration | intravenously |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Metabolism | Hepatic |
| Biological half-life | 60-80% in 72 hours |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 3778-73-2 |
| ATC code | L01AA06 (WHO) |
| PubChem | CID 3690 |
| DrugBank | APRD00007 |
| Synonyms | 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| Chemical data | |
| Formula | C7H15Cl2N2O2P |
| Molar mass | 261.1[[Script error: No such module "String".]] |
| (verify) | |
Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.[1]
It is sometimes abbreviated "IFO".[2]
Uses
It is given as a treatment for a variety of cancers, including:
- Testicular cancer
- Breast cancer
- Lymphoma (Hodgkin's and Non-Hodgkin's)
- Soft tissue sarcoma
- Osteogenic sarcoma
- Lung cancer
- Cervical cancer
- Ovarian cancer
- Bone cancer
Administration
It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous.
Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.
References
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<references />, or <references group="..." />External links
- ACS Drug Guide: Ifosfamide
- Harvard Medical School Health Information on Ifosfamide
- MedlinePlus Drug Information
- BC Cancer Agency Ifosamide Information (Professional)
- RxList Online Drug Index Ifosamide Listing
| 40px | This antineoplastic or immunomodulatory drug article is a stub. You can help ssf by expanding it. |
fr:Ifosfamide ja:イホスファミド pl:Ifosfamid pt:Ifosfamida ru:Ифосфамид sl:Ifosfamid
sv:Ifosfamid- ↑ Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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