Difference between revisions of "Thiamphenicol"

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Thiamphenicol
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Systematic (IUPAC) name
2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide
Clinical data
Pregnancy
category
  •  ?
Routes of
administration		 IV, IM, oral
Legal status
Legal status
  • none
Pharmacokinetic data
Bioavailability ?
Metabolism hepatic
Biological half-life 5.0 hours
Excretion renal
Identifiers
CAS Number 15318-45-3
ATC code J01BA02 (WHO) QJ51BA02
PubChem CID 27200
Chemical data
Formula C12H15Cl2NO5S
Molar mass 356.223 g/mol[[Script error: No such module "String".]]
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Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.[1]

References

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External links

  • Overview at World Health Organization - Food and Agriculture Organization
  • Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars). 64 (1): 33–8. PMID 15224555. 
  • Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy". J Chemother. 14 (6): 554–61. PMID 12583545. 
30S
-mycin (Streptomyces)
Tetracyclines
50S
Chloramphenicol#  · Azidamfenicol · Thiamphenicol · Florfenicol
EF-G
Steroid antibacterials

M: BAC

drug(J1p, w, n, m, vacc)


50px This systemic antibacterial-related article is a stub. You can help ssf by expanding it.
de:Thiamphenicol

fr:Thiamphénicol nl:Thiamfenicol ja:チアンフェニコール th:ไทแอมเฟนิคอล

zh:甲碸黴素
  1. ↑ Fuchs FD (2004). "Tetraciclinas e cloranfenicol". In Fuchs FD, Wannmacher L, Ferreira MB (eds.). Farmacologia clínica: fundamentos da terapêutica racional (in Portuguese) (3rd ed.). Rio de Janeiro: Guanabara Koogan. p. 375. ISBN 0-7216-5944-6. 
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