Thiamphenicol

Thiamphenicol

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Systematic (IUPAC) name
2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide
Clinical data
Pregnancy category	?
Routes of administration	IV, IM, oral
Legal status
Legal status	none
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Biological half-life	5.0 hours
Excretion	renal
Identifiers
CAS Number	15318-45-3
ATC code	J01BA02 (WHO) QJ51BA02
PubChem	CID 27200
Chemical data
Formula	C12H15Cl2NO5S
Molar mass	356.223 g/mol[[]]

Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.

External links

• Overview at World Health Organization - Food and Agriculture Organization
• Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars). 64 (1): 33–8. PMID 15224555. CS1 maint: Multiple names: authors list (link)
• Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy". J Chemother. 14 (6): 554–61. PMID 12583545. CS1 maint: Multiple names: authors list (link)

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