Teplizumab

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Teplizumab
Monoclonal antibody
Type Whole antibody
Source Template:Infobox drug/mab source
Target CD3
Identifiers
CAS Number 876387-05-2
ATC code none
Chemical data
Formula C6462H9938N1738O2022S46
Molar mass 145.8 kDa[[Script error: No such module "String".]]
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Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. It is in Phase-3 clinical trials for Type-1 DM. It targets at protecting the remaining beta cells in newly diagnosed T-1 diabetics. It has been used experimentally in type 1 diabetes mellitus[1], but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".[2]

Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).[3][4]

References

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External links

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†Undergoing clinical trials. §Never marketed.
Intracellular
(initiation)
Macrolides/
other IL-2 inhibitors
TNF-α inhibitor
Intracellular
(reception)
Extracellular
Serum target
(noncellular)
Cellular target
Unsorted
-cept (Fusion)


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