Nedocromil

Nedocromil

File:Nedocromil.svg
Systematic (IUPAC) name
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro- 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Routes of administration	Inhalation and eye drops
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Biological half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
CAS Number	69049-73-6
ATC code	R01AC07 (WHO) R03BC03, S01GX04
PubChem	CID 50294
DrugBank	APRD01137
Chemical data
Formula	C19H17NO7
Molar mass	371.341 g/mol[[]]
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Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.

References

de:Nedocromil pt:Nedocromil