Demecolcine
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| File:Demecolcine.png | |
| Systematic (IUPAC) name | |
|---|---|
|
(S)-1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one | |
| Identifiers | |
| CAS Number | 477-30-5 |
| ATC code | L01CC01 (WHO) |
| PubChem | CID 2832 |
| ChemSpider | 191135 |
| Chemical data | |
| Formula | C21H25NO5 |
| Molar mass | 371.43 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| (verify) | |
Demecolcine is a drug used in chemotherapy.It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl.
During cell division Demecolcine inhibits mitosis at metaphase by inhibiting spindle formation. Medically Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.[1]
In animal cloning procedures Demecolcine makes an ovum eject its nucleus, creating space for insertion of a new nucleus.[2]
References
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