Ifosfamide

Ifosfamide

File:Ifosfamide.svg
Systematic (IUPAC) name
N-3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide-2-oxide
Clinical data
Routes of administration	intravenously
Legal status
Legal status	?
Pharmacokinetic data
Bioavailability	100%
Metabolism	Hepatic
Biological half-life	60-80% in 72 hours
Excretion	Renal
Identifiers
CAS Number	3778-73-2
ATC code	L01AA06 (WHO)
PubChem	CID 3690
DrugBank	APRD00007
Synonyms	3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Chemical data
Formula	C7H15Cl2N2O2P
Molar mass	261.1[[]]
(verify)

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer.

It is sometimes abbreviated "IFO".

Uses

It is given as a treatment for a variety of cancers, including:

• Testicular cancer
• Breast cancer
• Lymphoma (Hodgkin's and Non-Hodgkin's)
• Soft tissue sarcoma
• Osteogenic sarcoma
• Lung cancer
• Cervical cancer
• Ovarian cancer
• Bone cancer

Administration

It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous.

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

External links

• ACS Drug Guide: Ifosfamide
• Harvard Medical School Health Information on Ifosfamide
• MedlinePlus Drug Information
• BC Cancer Agency Ifosamide Information (Professional)
• RxList Online Drug Index Ifosamide Listing

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